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The Science Behind Glyco-Flex Joint Supplements

glycoflex product group editedThe best nutritional supplements have ample scientific evidence that supports their use. Numerous studies provide evidence for the safety and effectiveness of the ingredients included in the Glyco-Flex line of joint supplements.

A 2007 study1 evaluated 16 clinical trials that looked into a wide variety of joint supplements. It found evidence in support of the following for the treatment of osteoarthritis in dogs:

  • Green Lipped Mussels (Perna canaliculus) 2,3
  • a combination of chondroitin sulfate (found in Green Lipped Mussels and other sources), glucosamine hydrochloride, and manganese ascorbate
  • Omega 3 Fatty Acids (found in Green Lipped Mussels and other sources)
  • polysulfated glycosaminoglycans (found in Green Lipped Mussels and other sources)
  • Avocado/Soybean Unsaponifiables (ASU)
  • P54FP (an extract of turmeric)
  • injectable pentosan polysulphate

The central active ingredient in Glyco-Flex is an extract derived from Green Lipped Mussels (Perna canaliculus). It is the sole active ingredient in Glyco-Flex Classic, making this formulation ideal for owners who are looking for a cost effective way to promote joint health in young dogs at risk for developing osteoarthritis or for those individuals in the earliest stages of the disease.

As osteoarthritis progresses, other Glyco-Flex varieties containing additional, beneficial active ingredients are recommended.

Glyco-Flex I is designed for younger dogs that need joint support and helps ease pain and inflammation caused by arthritis and other degenerative joint diseases. It contains:

  • Perna canaliculus (GlycOmega™ brand Green Lipped Mussel) 600 mg
  • Glucosamine HCI (Shrimp and Crab) 500 mg
  • N,N-Dimethylglycine HCI (DMG) 100 mg

Glyco-Flex II is typically prescribed to mature dogs who are suffering from moderate arthritis or hip dysplasia. This formulation is made from:

  • Perna canaliculus (GlycOmega™ brand Green Lipped Mussel) 600 mg
  • Methylsulfonylmethane (MSM) 500 mg
  • N,N-Dimethylglycine HCI (DMG) 100 mg
  • Manganese (as Mn Amino Acid Chelate) 10 mg

Glyco-Flex III protects joint health in elderly dogs and dogs with arthritis that need maximum joint support. It contains:

  • Glucosamine HCI (Shrimp and Crab) 1000 mg
  • Methylsulfonylmethane (MSM) 1000 mg
  • Perna canaliculus (GlycOmega™ brand Green Lipped Mussel) 600 mg
  • N,N-Dimethylglycine HCI (DMG) 100 mg
  • dl-alpha Tocopheryl Acetate (Vitamin E) 50 IU
  • Calcium Ascorbate (Vitamin C) 30 mg
  • Manganese (as Manganese Amino Acid Chelate) 10 mg

As osteoarthritis progresses, combination therapy including a nutritional supplement containing several active ingredients scientifically proven to be effective in the treatment of osteoarthritis is the best way to keep dogs comfortable and active. Glyco-Flex is also available for cats and horses.


  1. Systematic review of clinical trials of treatments for osteoarthritis in dogs. Aragon CL, Hofmeister EH, Budsberg SC. J Am Vet Med Assoc. 2007 Feb 15;230(4):514-21.
  2. Evaluating Complementary Therapies for Canine Osteoarthritis Part I: Green-lipped Mussel (Perna canaliculus). Hielm-Björkman A, Tulamo RM, Salonen H, Raekallio M. Evid Based Complement Alternat Med. 2009 Sep;6(3):365-73.
  3. Clinical efficacy and tolerance of an extract of green-lipped mussel (Perna canaliculus) in dogs presumptively diagnosed with degenerative joint disease. Pollard B, Guilford WG, Ankenbauer-Perkins KL, Hedderley D. N Z Vet J. 2006 Jun;54(3):114-8



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